Клиническая медицина

Solovyeva A.A., d.m.s. Averyanov S. V., c.m.s. Gulyaeva O.A.

Bashkir State Medical University (Ufa, Russia)

Use of innovative technology inhalation of oxygen- xenon mixture at dental implantation (A literature review)

Abstract. Current problems in dental implantology is the problem of eliminating the fear of the upcoming surgery, an effective analgesia, due to soreness, lasting, traumatic ongoing operation. The operation without pain and fear is the foundation of modern dentistry. Innovative technologies in anesthesia is the use of oxygen-xenon mixtures.

Key words: innovative technology, Xenon, oxygen- xenon mixture

In the Russian Federation the use of medical Xenon (KseMed®) was first allowed by order of the Ministry of Health from 08.10.1999 № 363 "On the resolution of the medical use of drugs" as a means of inhalation anesthesia [1, 7]. For a long time the use of dental health Xenon is not found, it prevented the economic aspects and the lack of specialized medical equipment. Through scientific corporation "Biology Gazservis" unique device Stuckey was developed in 2006. It became possible to significantly reduce xenon consumption, making it more affordable method of xenon treatment on the dental admission. [2] June 23-24, 2011 at the Congress - the center of a special economic zone "Dubna", ZAO "ATOM-MED Center" together with JSC "Tyumen aerosols" were presented samples of the first batch of active drugs xenon mixture with oxygen under "Medksenon" trademark in aerosol, which has increased its availability.

The first experience of Medksenona when installing implants held in 2013 specialists of JSC "ATOM-MED CENTER" and professor of family clinics, IA Shugaylova "INTELSTOM". It was held a successful one-step installation of 2 implants mandible patient 65 years. Premedication with sedatives and atropine was not carried out. Inhalation drugs "MEDKSENONA" at a concentration of Xe: O2 = 70:30 was held for 3 minutes in the dental chair unit for xenon inhalation (xenon therapy) "MIGA-AMC -1". Consumption on the inhalation of xenon was 3 liters. Performed articaine anesthetic infiltration anesthesia in an amount of 1.5 ml by the standard method. The duration of surgery was 47 minutes. The patient was calm, able to moderate sedation. Blood pressure, pulse rate and SpO2 remained stable throughout the operation. After surgery, the patient self-rose from his chair. According to the patient's body is maintained relaxation, and his head was clear. Thus, the use of "MEDKSENONA" in dentistry implant and as premedication - additional analgesia and sedation, to relieve the patient of mental and emotional stress in the dentist's chair shown to be highly effective [3].

It is no exaggeration to call the application of the stunning results that actively develops and implements the chief doctor "AVERON" dental clinic Sitnikov E.V. at a reception in April 2011: "The use of xenon significantly increases the effects of other painkillers, analgesic effect is maintained up to 6 - 12 hours depending on the intensity of pain. For relief of severe pain, only one three-minute inhalation, with the patient's consciousness is stored. Xenon has the additional pronounced anti-stress effect. During the long-term implant operations, I use a combination technique of combining traditional and inhalation anesthesia with xenon. Patients after surgery feel great, leave the reception in a good mood. And, very importantly, through this procedure, the healing process is accelerated and flows smoothly. And most importantly - to ensure comfortable stay of patients in the clinic and in the future [4].

Results of clinical studies Sitnikov E.V. demonstrated chronology procedures oxygen-xenon inhalation to relieve pain after surgery, sinus lift with simultaneous implant placement: paresthesia of the extremities in 50 seconds, nystagmus in 1 minute and 15 seconds, a reduction in pain 1 minute 40 seconds, reducing pain 2 times - 2 minutes 25 seconds, maintaining the level of pain or in the initial 3 minutes 25 seconds. Inhalation Duration reached 5 minutes 05 seconds. The level of pain was further 15-20% of the initial VAS. In addition, the pain passed localized - concentrated in the upper jaw. Such pain intensity remained about 4 hours, and then decreased pain. [5] Xenon - immunocorrector known, it has a mild immunostimulation effect, anti-inflammatory effect, which will undoubtedly have a positive effect on the postoperative healing in dental implantation.

Pain sensitivity of tissues in the area of the proposed intervention implantalogic characterized by significant differences between patients: pain threshold is different in 19.3 times, and the endurance level of pain in 20.5 times in the studied group of patients [6]. According to clinical data after dental implant pain intensity on a scale of VAS after inhalation of oxygen-xenon mixture decreased to 46,8 ± 9,7 [7]. The available scientific evidence suggests that xenon can influence the formation of adaptation on tolerance type and can lead to a decrease in the activity of stress-realizing system. Xenon has an antistress effect through reversible blockade of synaptic transmission mediators of excitatory cells (MDA-receptors) through potentiation of effects inhibitory neurotransmitters (glycine, GABA) through blockade releasing hormone stress implement body systems (adrenalin, glucocorticoids), through the change of blood flow [8]. Therefore, the use of xenon therapy has a positive impact on the human body systems to adapt [9].

Thus, the analysis of data in the literature devoted to the study of oxygen-xenon mixtures, allows us to establish that the main advantages that characterize the innovative technology is a significant reduction in emotional stress, rapid onset of analgesia, a strong analgesic and anesthetic effect without loss of consciousness, lack of toxicity, teratogenicity, mutagenicity , biotransformation. Conducting innovative anesthesia is characterized by easy handling, as well as improves the effectiveness of treatment and to avoid a whole range of complications and side-effects of pharmacological agents. No wonder the noble gas Xenon anesthetic recognized third millennium. These qualities are necessary for a peaceful and relaxed state of the patient, which in turn will allow the dentist - surgeon to focus solely on the technical part of the operation, as well as create favorable conditions for the best possible postoperative wound healing and healing of the implant.

Bibliography:

1. The use of a xenon-oxygen mixture in pain and pain syndromes. Medical technology. FS number 2010/123 dated 02.04.2010

2. The use of inhaled xenon-oxygen in dentistry. Methodical recommendations. - Yekaterinburg Urals State Medical Academy, 2013-S.6-8.

3. JSC "ATOM-MED CENTER" [Electronic resource]. - Access: http://a-mc.ru/pervyj-opyt-primeneniya-medksenona-pri-ustanovke-implantov

4. Treatment of xenon - the future of dentistry today // Clinical Dentistry 2011. - № 4. - S. 66-67.

5. Sitnikov E.V. Experience of oxygen-xenon inhalation for the relief of postoperative pain during operations open sinus lift. // Problems of Dentistry, 2012. - № 2. - S.54-56.

6. Meerovitch V.I. Features of anesthesia during dental implantation. Dissertation, Moscow, 2005- C201.

7. Davydov N.S., Naumov S.A., Kostromitina G.G., Sobetova G.V., Eremin V.S., Rabinovich S.A., Babikov A.S. Oxygen-xenon inhalation in outpatient practice. 2013- C1-4.

8. Nazarov E.I., Vongay V.G., Glukhenkiy T.A. ozone-xenon stress correction. // Medical Almanac 2013. - № 3. - S.189-192

9. Naumov S.A., Davydova N.S., Kostromitina G.G. Xenon therapy method. Guidelines. - Yekaterinburg Urals State Medical Academy, 2007. - C23.