Kolbasina L.P., Fazel Hamid, Kolbasina M.V., Shuman M.D.

Crimea state medical university named after S. I. Georgievsky, Simferopol.

Influence of disadaptation on hormonal status in protractedly and frequently ill children at health resort stage of rehabilitation.

Adaptation is one of the fundamental properties of living matter, the result and mean of resolving internal and external contradictions of life. Adaptation is the evolutionary process whereby a population becomes better suited to its habitat. This process takes place over many generations, and is one of the basic phenomena of biology.

Adapatation ensures the viability of the organism to changing environmental conditions. Adaptation to normal and abnormal new conditions do not arise whether as a result of adaptation disorders that may lead to further exclusion and can be resolved only through a deep studing mechanisms of adaptation.

Disadaptation - a ceiling of human reaction to the conflict.

Together with the nervous and circulatory systems, the endocrine system is critical for the integration and coordination of various bodily functions.

The objective of our researching was to study the hormones of pituitary-adrenal axis of children long and often suffering with the symptoms of adjustment disorder as well as development in the health with physiotherapeutic methods of treatment on sanatorium stage of rehabilitation to correct exclusion processes.

The hormones of pituitary-adrenal axis is the complex system of interaction between pituitary gland and adrenal cortex that involves stimulation of synthesis and release by corticotropin-releasing factor and adrenocorticotropic hormone, and the negative feedback effect of cortisol. Release of CRH from the hypothalamus is influenced by stress, physical activity, illness, by blood levels of cortisol and by the sleep/wake cycle (circadian rhythm). Long-lasting increased and (or) decreased secretion of cortisol (the end-product of the HPA axis) or of GH is detrimental to health. This suggests that the activity of these hormonal axes is finely tuned toward homeostasia, tolerating limited prolonged homeostatic disruption.

We used survey data of 86 children of both sexes aged 9 to 13 years who were at a health resort on a stage of rehabilitation in Eupatory Resort “Ubilenjy” and with a history of diagnosed “long and frequently have being ill”, mostly with chronic desiases of naso-pharyngealarea. All the children were divided into two groups. The first group included children received conventional therapy(35), while the second group – 51 children , received a package of physiotherapy developed by us , which included the using aromatherapy dosed drug “Polyol”, a mixture of oil rose, lavender, sage and coriander and they also using the applicator Lyapko. Investigation of hormonal status survey was conducted by enzyme-linked immunoassay, which determined the quantitative concentration of cortisol in the blood serum.

Quantitatively concentrations of adrenocorticotropic hormone ( ACTH) in blood plasma was determined by two-step enzyme immunoassay.The resulting data were processed using correlation statistics and calculation by Student criterion. Considered reliable indicators were at p<0,05. Upon admission of children, long and frequently have being ill with maladjustment symptoms, revealed a significant shift in the state of hormones of pituitary-adrenal axes.

Since the content of cortisol was 239,34±19,18 nmol/L, it as at 16,1%(p<0,05) lower than benchmarks, and the level of ACTH was 52,88±10,84 pg/ml, which was 28>5%(p1<0.01) above control. Using the complex of physiotherapeutic methods has led a slight decrease in hormonal imbalance , which in the study group continued up to 7 days stay in the sanatorium ,and was; cortisol – 249,69±21,42 nmol/L (pl<0.05, P2>0,05, p3<0,05) ACTH – 47,65 10,95 pg/ml (P1 < 0,01, p2>0,05, p3<0,05). On the 10^th day the children of the first group indicators studied hormones significantly decreased , getting compared to control statistically insignificant nature (P1>0,05). On the 14^th day there were no differences between cortisol and ACTH levels from control , gaining relative to the index of the level of hormones at the time of admission to a sanatorium (p2) meaningful(p2<0,05). Analyzing the hormone level of children in second group of observations receiving the traditional methods of correcting unadaptation , in this group of hormonal disbalance observed on 10^th day. The maintenance of cortisol was below the benchmark at 14.7% (pl(0.05), and ACTH - higher at 15,1% (p<0.05) .On the next 14th-16^th days of hormone approaching benchmarking acquiring statistically significant were compared to the rates at the time of admission (p2<0.05) only in 16^th day.

Thus , the researching hormones of pituitary-adrenal axes has allowed us to conclude that the childrens suffering from naso-pharyngeal pathology have being ill 4th-5^th times a year , developing hormonal imbalance, which we regarded as a violation of adaptation. Using traditional methods of correction reduced the effects of malajustment only on 14th-16^th days of spa treatments, while the using the complex of physiotherapy techniques the processes of adaptation on 10-14^th days , as a convincing hormone bachground shows.