Avdusenko M., Bogdanova T.

Donetsk National Medical University, Liman, Ukraine.

Research of an Oral Fluid Biochemical Indicators Influence to the Teeth Caries Resistance of Children with Undifferentiated Connection Tissue Dysplasia Syndrome

Introduction: A connection tissue performs an important functions in a child’s organism, reacts to all physiological and pathological effects. Its developmental disability is named as a connection tissue dysplasia. There is a lack of knowledge about an influence of undifferentiated connection tissue dysplasia to a caries resistance of a teeth enamel in a modern literature. Mineralizing characteristics of a saliva and an oral fluid are based on mechanisms preventing an enamel depletion of its components, facilitating such components penetration from a saliva to enamel. A calcium contains in a salvia in an ionic and an associated condition. An acid-based dyscrasia activates a proteoclastic degradation of proteins, namely of the teeth pellicula components, and intensifies demineralization of enamel. The ionic bonds appearing between calcium and proteins, prevent to a calcium salts sedimentation. Approximately 15 % of calcium quantity belongs to a protein bound. It forms a saliva pellicula at the surface of enamel, protects, performs agglutination of bacteriums and has a great importance preventing caries.

Purpose. Determining a dependency between a teeth enamel caries resistance characteristics of children 10-12 years old, affected by undifferentiated dysplasia of connection tissue, having a calcium and total protein in an oral fluid.

Materials and methods. 50 children at the age from 10 to12 years were explored. Concentration of calcium and total protein in oral fluid was determined by means of biochemical studies. The teeth enamel caries resistance was determined using enamel resistance test of Okushko V.R. There are 30 children with undifferentiated connection tissue syndrome were referred to the first (the main) group, 20 conditionally healthy children were referred to the second (control) group. The data received was processed by means of a table editor Excel and a statistic package Statistica 6.0

Results. Average results of biochemical values of oral fluid of children from the main group were certainly less, than the same control group. Concentration of calcium is (0,88±0.02) mmol/l and (1,23±0.04) mmol/l correspondingly, with a significance of differences р<0,01. The same of total protein (0.87±0.04) g/l and (1.55±0.08) g/l, with a significance of differences р<0,02. Performance of enamel resistance test showed that in the first group of children this parameter equals to (5.83 ±0.36) points, the same of children from the control group equals to (4.15±0.22) points, with a significance of differences р ≤ 0,05. There was received a statistically significant back correlation relationship between values of enamel resistance test and concentration of calcium in oral fluid for children of the main (r=‑0,66; p<0,05) and control (r=‑0,49; p<0,05) groups. So that to consider a simultaneous influence of calcium content and total protein for dental enamel caries resistance, there was added the product function based on a theorem of two independent events multiplication. As a result a statistically significant strong interconnection for children of the first group (r=‑0,86; p<0,05) and a statistically insignificant interconnection for children of the second group(r=‑0,403; p>0,05) were revealed.

Conclusion. Medium of biochemical values of calcium and total protein contain in oral fluid of children from the main group are significantly lower than the same of children from the control group. There was received a strong statistically significant back interconnection between the values of caries resistance of dental enamel and content of calcium and total protein in oral fluid of children 10-12 years old affected by undifferentiated connection tissue dysplasia, which approves that children’s enamel of this group is subject to influence not only by calcium content in oral fluid, but also total protein content.

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