Медицинские науки/ 1. Акушерство и гинекология

Medical sciences / 1. Obstetrics and Gynecology

Syusyuka V.G., Peycheva E.V.

State Medical University of Zaporozhye

Department of Obstetrics and Gynecology

Maternity hospital No. 9, Zaporozhye

Estimation of level of catecholamines

of pregnant women with regard to

psychoemotional state

One of important questions both in obstetrics and pediatrics is the estimation of interconnection of mental state and complications during pregnancy which naturally have influence on fetation, result of delivery and further state of baby. Anxiety of the mother during stress causes disorders in functioning of her organs and systems besides it disturbs biochemical balance of the fetus leading to hyperactivation of sympathoadrenal system (SAS) [7].

State of the pregnant woman can have significant influence on features of the prenate psychological functions which are being formed and therefore it can considerably determine his life scenario [2].

Object of investigation: to estimate mutual influence of sympathoadrenal system and psychoemotional state of the pregnant women.

Group of examined persons and methods of investigations Based on estimation of psychoemotional state and factors of sympathoadrenal system of 30 pregnant women in II and III trimesters (27.9±1.73 weeks). Average age of the women under examination was 26.23±1.50 years. Psychoemotional state of the pregnant women was estimated based on structured interview, questionnaire and psychological tests (Spielberg-Hanin tests, test of the pregnant woman attitude, Personality Questionnaire of the V.M. Bekhterev Institute (PQBI) [1, 4, 5, 6]. Level of dihydroxyphenylalanine (DOPA), dopamine (D), noradrenaline (N) and adrenaline (A) was defined in urine collected during 24 hours by means of unified method of Matlina E. Sh. and co-authors [3].

Results of investigation and their discussion

Based on psychological component of gestational dominant (PCGD) of pregnant women of the examined group, the optimal type of PCGD was detected in 43.3% of women. According to the data of anxiety self-assessment there was revealed that in 46.7% of cases the level of state anxiety was low but during estimation of trait anxiety its low level occurred only in 6.7% of pregnant women. Similarity of biosynthesis of cathecholamines and DOPA is confirmed by available correlated relations of level of DOPA with D (r = +0.553, p < 0.05) and D with A and N (r = + 0.417, p < 0.05). Taking into account positive correlation of A and N level with test results which characterize hypogestognozic type (r = + 0.511, p < 0.05) and correspondingly euphoric type (r = +0.443, p < 0.05) of PCGD and also negative correlation - N level with optimal type (r = - 0.441, p < 0.05) the change of SAS hormones with regard to PCGD should be estimated. Thus, among the pregnant women with optimal type of PCGD, N level (18.31 ± 2.32) was statically and evidently (p < 0.05) lower than the correspondent index of women with type deviating from the optimal one (41.73 ± 21.48). Among other hormones the same tendency is observed but statistically evident difference (p > 0.05) was not found. The interesting fact is that the pregnant women with type deviating from the optimal type of PCGD have the state anxiety (ST) level which positively correlates with the test results characterizing the anxious type (r = + 0.509, p < 0.05).

Conclusions

1.

According to the estimation results of level of cathecholamines (adrenaline, noradrenaline, dopamine) and DOPA there is observed a common tendency for increasing of their level which have the pregnant women with type deviating from the optimal type of PCGD in comparison with the women having the optimal type. However statistically evident difference (p < 0.05) was found only during estimation of noradrenaline level (41.73 ± 21.48 and 18.31 ± 2.32 microgram/24 hours correspondingly). Such changes can indicate intenseness of mediator link of sympathoadrenal system.

2.

During estimation of factors of cathecholamines and DOPA of pregnant women with optimal type and type deviating from the optimal one of PCGD the static evident difference (p > 0.05) was not found. However it should be mentioned that exactly the absence of static evident difference (p > 0.05) of DOPA/A+N+D enables to suppose good compensation abilities of the pregnant woman organism at the moment of investigation.

Literature

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