/ 4.

 

... . ., ... * . ., ... . ., ... . ., . .

..

* -

- .

() . ( .., 2000). 37,6%. : , . , , .

- , , - (), (Jeunemaitre X., 1992, Schunkert H. et al., 1994; Iwai, 1994). ACE, (insertion) (deletion) Alu 287 16 (Soubrier F. et al., 1988). (DD) ACE , ACE , I II (Danser A.H. et al., 1995). , D, , (Shunkert H., 1994). I/D ACE (Glavnik N., 2007).

1 (21), - , , . 10 21. 1166. (Fan H., 1998). 21 (Castellano M. 1996, Schmidt S 1997).

, - ACE 1166 21 (, ) , .

303 100 . ( , , , , 12 , ()). () ≥140/90 ... (/, 1999; , 2001).

. - (n=101, 51,30,9 ) 14,31,1 . 100 - ( 52,20,8 , - 11,00,7 ). (n=102, 51,11,1 , - 13,01,2 ). (175,62,8 I , 178,73,0 . . II 168,42,3 . . III ) (104,11,4, 106,71,4 99,91,3 . .) .

- . .. .

Statistica for Windows 6.0 (StatSoft). t - - . χ2. , , < 0,05.

.

- ACE , 1.

1. .

II%

ID%

DD%

. I %

. D %

33,3

44,9 *

21,8 *

56, 5

43,5

25

42,5

32,5

46,3

53,7

33,3

43,3*

23,4*

55,0

45,0

*p< 0,05

, , , ID.

, ACE , DD. , ID . , ( ) , , ID, ( 2).

2. ,

II %

ID %

DD %

. I %

. D %

34,2

41,5

24,2

55,8

44,2

32,0

52,0

16,0

60,0

40,0

20,0

56,7

23,3

56,7

43,3

40,0

-

60,0*

40,0

60,0

 

30,0

43,3

26,7

51,7

48,3

40,0

43,3

16,7

63,3

36,7

*p< 0,05

, DD , , , , ID, - .

. , . (p<0,05), 100% ID.

2R1 , , .

2R1 , ( 3).

2R1 , . , ..

3. 2R1

%

%

%

. %

. %

61,8*

30,9

7,3

80,1

19,9

 

70,8*

25,0

4,2

85

15

61,4*

37,3

1,3

77,2

12,8

 

73,3*

23,3

3,4

83,3

16,7

68,4*

29,0

2,6

82,9

17,1

 

82,1*

17,9

-

91,1

8,9

*p<0,05

2R1 ,

, , , (DD - 60% ID -100% ). 2R1 , .

 

1. .., .. - XX : , , . 2000; 40 (4); 4-8.

2.Castellano M. Angiotensin II type 1 receptor A/C 1166 polymorphism. Rela
tionships with blood pressure and cardiovascular structure / M. Castellano, M.
Muiesan, M. Beschi et al. // Hypertension. - 1996. - Vol. 28, 6. - P. 1076-
1080.

3. Jeunemaitre X., Lifton R. P., Hunt S. et al. Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nature Genet 1992; 1; 72-5.

4. Iwai N., Ohmichi N., Nakamura Y., Kinoshita M. DD-genotype of angiotensin-converting-enzyme gene is risk factor for left ventricular hypertrophy. Circulation 1994; 90:2622-2628.

5. Fan H, Li S., Gu W et al. Association between angiotensin II type 1 receptor gene and human essential hypertension. Chung Him I Hsueh I 2 Chuan Hsueh Tsa Chin. - 1998. -Vol. 15, 2. -P.101-103.

6. Rigat ., Hubert ., Alhenc-Gelas F et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. Clin Invest 1990; 86; 1343-46.

7.Schmidt S, Beige. J, Walla-Friedel M et al. A polymorphism in the gene for the angiotensin II type I receptor is not associated with hypertension. J. Hypertens.-1997.-Vol. 15, 12, Pt. l.-P. 1385-1388.

8. Schunkert H., Hense H.-W., Holmer S. R et al. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. New Eng J Med 1994; 330;1634-8.

9. Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G, Corvol P. Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc.Natl.Acad.Sci.USA.1988; V.85.P.9386-9390.

10. Danser AH, Schalekamp MA, Bax WA, van den Brink AM, Saxena PR, Riegger GA, Schunkert H. Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation 1995; 92: 13878.

11. Glavnik N, Petrovic D. M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians. Folia Biol (Praha) 2007; 53(2):69-70.