UDC:
616-94-022-053.31.612
IMMUNE STATUS PARAMETERS IN PERIOD OF THE VACCINAL
PROCESS IN CHILDREN WHO HAVE HAD SEVERE BACTERIAL INFECTIONS
L.D.Mullaeva
Republican
Specialized Scientific-Practical Medical Center of Pediatrics the Ministry of
Health of the Republic of Uzbekistan
The consequences of
transferred or carried septic infection are violations of the functioning of
various organs and systems, including the immune system, which plays an
important role in the outcome of this disease. Follow-up study revealed the preservation of
these disorders during the first year of life of child, what could reduce the
effectiveness of immunization against preventable diseases in this category of
children. This circumstance led to the purpose
of the present investigation in the need for a deeper study of parameters of
the immune system in children who have had bacterial sepsis.
Materials and methods: We had
been lead research of immune status in 74 children after transferred or carried
sepsis first few months of life, before the introduction of vaccination in the
ages of 6 months to 1 year. Assessment of
immunological parameters was performed prior to vaccination with the definition
of cellular and humoral of immunity as well as non-specific defense. For a more detailed assessment of immune disorders
assessed the degree of immunological disorders (IDAs) by a universal formula
proposed by AM Zemskov (1986) and by method of frequency analysis. Additionally diagnostic value of the coefficient was
calculated using the formula by AD Gorelik and VA Skrypkina (1974), followed by
determination of leading immunological parameter - formulas of disorders
of immune system (FDIS) by method of A.M. Zemskov (1986).
Results: In children who had undergone sepsis, prior to
vaccination revealed serious violation of immune status, expressed in short
supply of T-cell system, by phagocytosis and dissimmunoglobulinemia. Frequency analysis allows to objectively
characterizing the risk of forming of pathological changes of high 2-3 degree of
immunological parameters in the
surveyed groups of children. In children who had undergone sepsis immune
disorders are characterized by a decrease of lymphocyte 2nd degree in 91.3% of
T-cell 2nd degree in 86.9% and 3rd degree in 13.1% of examinees, B-lymphocytes
2nd degree in 80.4% and 3rd degree in 19.6% of children. In this category of children revealed a significant reduction in
the absolute number of CD4, CD8, and CD16 in the range degree 2-3, indicating a
depression of T-cellular link of immunity. As
well there was a slight decrease in phagocytic activity of neutrophils - FAN
(19.6%) and the level of IgG (8,7%) second degree, in children who had undergone sepsis. In the study of
immunoglobulin IgA revealed a reliable increase in the third degree, 100% of
examinees children. Analysis of the degree of
immune disorders and the calculation of the coefficient diagnostic value gave
the possible to compile a list of changed immunological parameters in children
who undergone sepsis: Lymph²-CD4 ³-CD8 ²-T ² - SD16
²-Vl ²-IgA ³ + FAN ¹-IgM ¹ + IgG ¹-. Key indicators were entered into the formula
disorders of the immune system (FDIS) Lymph ²-³-CD4 CD8 ²-T
² -.
In
such a way, children who have had sepsis were observed the significant suppression
of the immune status, the high frequency of immune disorders degree 2-3. About
a third of children have had undergone sepsis, on the named parameters, in period
of the introduction of preventive vaccinations are stored important changes of
immunological parameters. Consequently, to this category of children necessary
in period of disease corrections of immunological parameters for the purpose of
rehabilitate and prepare them for subsequent vaccination against preventable
diseases.