Kushnir K.G., Severinova S.K., Lavrovskaya O.M.

Crimea State Medical University named after S. I. Georgievsky

"Adaptation of the patients after dental implant against the therapies"

The actual problem of regenerative medicine is to increase the effectiveness of rehabilitation measures aimed at improving the backup and the adaptive capacity of various organs and systems. In this regard, the development of methods for the prevention of complications in a new direction of modern prosthetic dentistry - implant is extremely important and urgent task.

Cases of rejection of implants are very rare and account for 0.4% - 4%. This means that the risk of complications after implantation of teeth is significantly lower than with classical bridges.
Benefits of dental implants:

-High aesthetic effect. Dental implants is externally indistinguishable from natural teeth.

-Reliability and functionality. Through the use of high technology and durability of implants, you can eat any food.
- Exclusivity. Only with the help of dental implants can restore a single tooth without disturbing the rest of healthy teeth.
- Small size. Can significantly reduce the size of the prosthesis and reliably attach.
- High service life. Dental implants are 5-25 years old. If you wear can easily be restored by taking the original appearance.
Given the important role the state of the natural resistance of the body in the healing process, for stomadont and the human body as a whole would strengthen its defenses, has a normalizing effect on a variety of structural and functional abnormalities in the periodontal tissues after implantation, and the whole organism. Therefore, the search for new effective treatments that enhance the regeneration of damaged periodontal tissues, I still relevant today.

In our study, to improve the adaptation of patients after dental implants and prosthetics further we applied the domestic preparation of the new generation has been widely used in medicine, adaptogenic and immunomodulator Erbisol. A characteristic feature is its ability to enhance the activity of controlling the homeostasis of body systems and thus affect the pathological processes in the body, remaining virtually indifferent to the healthy organism.

Erbisol mechanism of action is based primarily on the activation of macrophage cells, which play an important role in the repair and regeneration. Experimental and clinical studies have shown that Erbisol is effective in activating reparative and regenerative processes and innate immunity contributes to suppression of inflammation and restoration of functional activity of organs and tissues has Membrane stabilizing and anti-oxidant properties.

The aim of our study was to investigate the timing of adaptation and the impact on them of immunomodulator Erbisol by monitoring the rate of patients with metal orthopedic prostheses fixed on titanium implants.
To study the functional state of the oral tissues - facial elected salivation speed results in 31 patients after implantation of the prosthesis and metal-ceramic fixed restorations, as the salivary glands are an objective measure to determine the overall and local disease. Within the group were identified: subgroup A (15 patients) - without the use of therapies and subgroup B (16 - patients) - patients after fixation of permanent structures in the daily / m in the gluteal muscle was administered the drug "Erbisol" to 1 ml, the course of 10 days . Also examined 15 healthy individuals who do not have dental pathology - a control group. The study was conducted in mixed saliva within 1, 2, 3, 4, 5, 6 months after fixing prostheses implants.

Analysis of the results showed the rate of salivation that by 1 month follow-up period of prosthetics in the rate of salivation were statistically insignificant nature in relation to the control of both studied subgroups.

By 2 months of follow-showed a statistically significant increase in the rate of salivation and as a sub-group A and in group B, which we regarded as a reaction to the salivary glands in the prosthesis.

By 3 month after prosthesis was observed cascade of speed increase salivation in patients of both subgroups, but particularly pronounced in the subgroup A (without drug therapy Erbisol), where they were 0,95 ± 0,032 ml / min., Which was 39.0% higher benchmarks (p <0,001).

By month 4 in group A were speeds salivation 0,85 ± 0,033 ml / min. Which was 25.0% higher than the control, while in group B pattern was different, where the values acquired statistically significant with respect to the nature benchmarks and were 0,79 ± 0,030 ml / min (p <0,05).

In the following observation periods of 5-6 months in group A and in group B performance speed control salivation were approaching.

Thus, the above rate monitoring salivation when installing fixed prosthesis to implant allowed to come to the conclusion that to the 2 month after prosthesis growth rate of salivation occurs in all studied subgroups, which we attribute to the body's reaction to the prosthesis.
Using immuno "Erbisol" is a shortened adaptation to prostheses for 1-1.5 months, which is strong evidence to earlier normalization speed salivation in patients subgroup B. In addition to the above, patients in the integrated treatment of which was included immunomodulator and adaptogen Erbisol , noted the increase of efficiency, improvement of health less susceptibility to colds in the observation period.