Roganov G.G., Kushnir K.G., Nepreluk O.A.,Shuman M.D.

Crimea state medical university named after S. I. Georgievsky

The influence of fixed prostheses based on endosseous dental implants on enzymatic activity of saliva

Summary

The indexes of antitripsine activity of mixed saliva in orthopedic patients with using different types of dentures set on implants allowed to make a conclusion , that the indexes of normalization of patients, who used ceramic dentures for 3-4 months compare to patients , that used metaloceramic dentures – for 5-6 months. The use preparation “Erbisol” considerably improves the adaptation of organism.

Key words : physical development, height,weight,body mass index.

Last years the implantology has become very popular. The fixed prostheses based on implants allow to reestablish aesthetics, the chewing function, give to the patient the sense of comfort and confidence.

In oral cavity metalic implants react and change enzymatic activity of the saliva. The important problem is factor of compatibility of metalic alloys of different by structure and chemical nature.

The purpose of our investigation is study the dynamics of anti tryptic activity of saliva as a criteron of estimation the processes of adaptation during the use different types of fixed prostheses based on titanium implants.

Material and methods

The material of our investigation was mixed saliva , taken from 62

patients. Selecting the patients we considered the general condition, suffered and related diseases. For observations were formed 2 groups , in each group – 2 subgroups.

In first group were patients, who after dental implantation carring out installated metaloceramic prostheses based on cobalt-chromium alloy Duceralloy. First goup included 38 patients, second group – 24 patients. Second group included patients, whom during the prosthetics manufactured non metal ceramic prostheses based on implants.Each group divided on 2 subgroups: subgroup A – with no additional therapeutic actions, subgroup B - the patients after fixation of dentureshad injection of Erbisol 1 ml, course 10 days.

The preparation “Erbisol” is immunomodulator, reparant, and adaptogen.

The mixed saliva was collected in 1,2,3,4,5,6 months after fixation the prostheses based on implants. Antitrypsin activity of saliva determined by electrophotometric Chevar method.

Results and discussion

During the analysis of antitrypsin activity of saliva in orthopedic patients after prosthetics revealed , that by 1 month of observation in all groups the indexes were different from control not significantly and had statistically non-significant character (p>0,05).

By second month of investigation noticed the increase of antitrypsin activity indicators in all group of investigation . In first group , where used metal ceramic prostheses, in subgroup A (with no use Erbisol) – the indexes were 169,34±11,24 Mkm/l, that 17,2 % higher than control indexes; in subgroup B(with Erbisol use) – 167,88 ±17,24 Mkm/l, that 15,5 % higher the norm.

By 3 month of observation noticed progressive increase of indixes of antitrypsin activity of mixed saliva in 1 and 2 group,especially expressed in in 1A subgroup – 135,75±10,33 Mkm/l, that 27,8 % higher than control with p<0,01).

By 4 month after prosthetics the indicators of antitrypsin activity of saliva in 1 group stayed on high level (in subgroup A – 23,6 % higher, in sungrop B – 20,4 % higher than the norm); at the same time in 2 group – has statistically not significant character.

In next terms of investigation (5-6 months)the indicators of antitrypsin activity of mixed saliva in all groups were approaching to the control.

In this way, the biochemical observation of antitrypsin activity of mixed saliva in orthopedic patients with using different types of fixed prostheses based on implants has showed that the increase of enzymatic activity after prosthetics observed not dependently from type of fixed dentures.

Conclusions:

1. The carrying out the orthopedic treatment by fixed prostheses based on titanium implants cause the increase of indexes of antitrypsin activity of mixed saliva and not depend from type of fixed prostheses.

2. The terms of adaptation after carried out proshetics are different in observed groups:minimal – with using non metal ceramic prostheses(3-4 months), and with using metal ceramic prostheses – 5-6 months.

3. The use preparation “Erbisol” significantly decrease the terms of adaptation of orghanism after proshetics in all group of observation.