Medicine /4. Therapy

Bastrikov O.Yu., Belov V.V., Grigoricheva E.A.,

Sumerkina V.A., Evdokimova E.V., Il'inyh E.I., Ozhigina E.V.

South Ural State Medical University (Chelyabinsk)

Gender features metabolism of lipoproteins in correlation with psychoemotional factors in practically healthy individuals

 

Introduction. Currently, along with a certain influence has become "traditional", new risk factors of cardio - vascular diseases (CVD), the impact of which is still poorly understood and / or which are not taken into account. Among them psychoemotional stress and anxiety - depressive disorder may have on human health more impact than the already well-known, acting either directly or through "traditional" risk factors, enhancing the effect of the latter [1]. The psychosomatic approach to the problem of physical illness as a result of emotional stress involves the study of possible biochemical mechanisms of stress-induced reactions: dyslipidemia, activation of free radical oxidation, "pro-inflammatory" cytokine imbalance ergic processes, the immune system with the development of inflammation [2]. In the literature, there is a lot of evidence that acute and especially chronic psycho-emotional stress causes the disorder of lipid metabolism. According to P.D. Gorizontov "hypercholesterolemia - is an expression of metabolic stress" [3]. In turn, the stress situation is an indicator of the relationship between mental health and neuroendocrine regulation. According to some reports, this relationship is due to the simultaneous effect of stress on lipid profile, and on the development of physical illness. Therefore, dyslipidemia is a prognostic factor for the development of cardio - vascular diseases and other non-communicable diseases. It is relevant to study the effects of the relationship of blood lipid metabolism and psychobiology of stress from a gender perspective.

Purpose: examine gender features metabolism of lipoproteins in correlation with psychoemotional factors in practically healthy individuals.

Material and methods. Cross-sectional study of 213 employees of the enterprise of the poultry-farming industry of Chelyabinsk region is conducted. Exclusion criteria: III group health pursuant to the Order of Ministry of Health of the Russian Federation № 1006n 03.12.2012, myocardial diseases, heart racing, connective tissue dysplasia, arterial hypertension (according to primary medical documentation and autometrii), chronic administration of antihypertensive and lipid-lowering drugs, secondary dyslipidemia, acute illness, negativity on ultrasound. The study included 107 practically healthy people of working age from the organized population (46 men and 61 women) with a mean age of 43,4 ± 10,8 years. All included in the study was carried out additional clinical - laboratory and instrumental examination, including an assessment of CVD factors, biochemical screening, a two-fold measurement of blood pressure, echocardiography, electrocardiography in standard 12-lead ECG with subsequent evaluation - categories by Minnesota code [4]. Assessed behavioral and biological risk factors: age, smoking, poor diet, alcohol consumption status, level of physical activity at work and at home, the degree of labor intensity, overweight and abdominal obesity, family history (cases of death from CVD at an early age in close relatives ) [5]. All the surveyed people filled in psychological tests using questionnaires: Spielberger-Hanina test [6]; Center for Epidemiologic Studies Depression Scale (CES-D) [7]; visual-analogue scale (a modified version of the method Dembo-Rubinstein) [8]; the level of social frustration [9]; the test of social adaptation Holmes- Rahe [10].

Fence venous blood lipid profile parameters for the study was carried out on an empty stomach in the morning, after a 12-hour fast. Determination of the concentration of total cholesterol (C), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) in the blood serum was carried out by an enzymatic colorimetric method using a reagent kit by "Olvex Diagnosticum" (Russia) at the biochemical analyzer Stat Fax 3300 (USA) , the level of low density lipoprotein cholesterol (LDL - C) was determined by calculation on the Friedewald formula: LDL-C = total cholesterol - HDL - HDL - TG / 2.2, the calculation of the level of cholesterol very low density lipoproteins (LDL - VLDL) using the formula VLDL = TG / 2,2, atherogenic index (AI) was calculated according to the formula proposed by A.N. Klimov: AI = total cholesterol (mmol / l) - HDL-C(mmol / l) / HDL-C (mmol / l) [11]. Non-HDL cholesterol (Non-HDL-C) defined by the formula = total cholesterol HDL-C [12]. Determination of apolipoprotein B 100 (apo B100) and apolipoprotein A1 (Apo A1) in serum was performed immunoturbodimetricheskim method using a reagent kit of the company «Human» on automatic ELISA analyzer Bio Chem Analette EIA (HTI, USA). Statistical analysis of the material was carried out using statistical software package SPSS for Windows version 17.0. Evaluating the differences variables for independent samples were performed using t-test. In the case of the distribution of values different from the normal, using a non-parametric Mann - Whitney U. Comparison of groups was carried out by attributes using the crosstabs with Pearson Chi-Square. To identify the relationships between the studied parameters was performed correlation analysis using Spearman's rank correlation coefficient (r). In order to select the most significant variables affecting the variability of quantitative variables studied, used the method of multiple stepwise linear regression. In all procedures of statistical analysis the level of significance was taken as p<0.05.

Results and discussion. The analysis of the data showed that the vast majority of average lipoprotein metabolism, responsible for the atherogenic potential was significantly higher in the group of males surveyed. When comparing the mean value of Apo-A1 between-group differences were found. The level of "good" cholesterol was significantly higher in women (Table 1). Gender characteristics of lipid studied in different populations, including living in extreme climatic conditions. So according to the epidemiological study conducted in the indigenous population of the Republic of Sakha (Yakutia), no statistically significant gender differences in the content of total cholesterol, LDL cholesterol and triglycerides. In women, the concentration of HDL cholesterol was higher than that of men. In men, compared with women who had higher values of atherogenic index [13].

Table 1

Average performance indicators lipoprotein metabolism in the two groups,

M [95% CI]

The indicator unit. edited.

Male group

(n=30)

Female group

(n=41)

C, mmol/l

5.59 [5.06-6.12]*

4.82 [4.31-5.34]*

TG, mmol/l

2.07 [1.30-2.84]*

1.13 [0.96-1.31]*

HDL-C, mmol/l

1.19 [1.11-1.27]*

1.37 [1.30-1.45]*

LDL-C, mmol/l

3.56 [2.98-4.14]*

2.94 [2.43-3.45]*

HDL - VLDL, mmol/l

0.84 [0.64-1.05]*

0.51 [0.43-0.59]*

LDL-C & VLDL, mmol/l

6.27 [5.28-7.26]*

4.56 [4.02-5.10]*

AI

3.86 [3.33-4.39]*

2.64 [2.16-3.13]*

Apo-А1, g/l

1.09 [1.03-1.16]

1.11 [1.07-1.16]

Apo-В100, g/l

1.17 [1.08-1.26]*

1.06 [1.00-1.12]*

Apo-В100/Apo-А1 ratio

1.09 [1.00-1.18]*

0.95 [0.90-1.01]*

Non-HDL-C, mmol/l

4.27 [3.79-4.75]*

3.45 [2.91-3.98]*

*hereinafter p<0.05

A statistically significant gender differences in the frequency of TG and increased content of apo-B100. Currently, hypertriglyceridemia, and Apo-B are considered as valid criteria for evaluating new cardiovascular risk [14]. The most common types of atherogenic birefringence of the population studied were elevated levels of Apo - B100, Non-HDL-C, Apo-V100/Apo-A1 ratio. In men, except for the above, the share of isolated hypercholesterolemia and hypertriglyceridemia accounted for 40% (Table 2).

Table 2

Frequency dyslipoproteinemia among healthy individuals, abs. h (%)

 

The indicator unit. edited.

Male group

(n=30)

Female group

(n=41)

χ2

p

hypercholesterolemia

(atherogenic index of more than 4)

12 (40%)

8 (20%)

0.06

 

hypertriglyceridemia

12 (40%)

7 (17%)

0.03

*

hypercholesterolemia

& hypertriglyceridemia

8 (27%)

4 (10%)

0.06

 

hypercholesterolemia, reduced level HDL-C

4 (13%)

6 (15%)

0.88

 

hypertriglyceridemia, reduced level HDL-C

6 (20%)

7 (17%)

0.75

 

reduced level HDL-C

6 (20%)

11 (27%)

0.51

 

hypercholesterolemia

& hypertriglyceridemia & reduced level HDL-C

4 (13%)

4 (10%)

0.64

 

elevated Non-HDL-C

22 (73%)

15 (37%)

0.38

 

elevated Apo B100

26 (87%)

22 (54%)

0.003

*

elevated Apo-В100/Apo-А1 ratio

19 (63%)

14 (37%)

0.83

 

 

The average parameters of psychological testing in healthy individuals by gender are presented in Table 3. Identified the following gender-specific psychological status. The assessment of visual - analogue scale health, stress, resilience, level of social frustration and reactive anxiety intergroup differences were found. Average performance level of depression, trait anxiety and evaluation of accumulated stress on a scale of Holmes-Rahe were significantly higher in the group of women. At the inter-group comparison of psychological factors expressed in quantitative characteristics (absolute and%), it was found that in the female group compared with men significantly more frequent in persons with clinically significant level of personal anxiety (respectively 46 (75%) and 22 (48%) and stress accumulated scale Holmes - Rahe (respectively 22 (36%) and 6 (13%) (p < 0.05).

Table 2

The average parameters of psychological testing in the two groups, M [95% CI]

 

The indicator, points

Male group

(n=46)

Female group

(n=61)

health self-assessment

68,6 [61,9-75,4]

62,1 [56,1-68,1]

stress self-assessment

38,6 [29,5-47,7]

45,5 [38,8-52,3]

resilience self-assessment

64,3 [54,0-74,6]

60,8 [54,0-67,6]

level of a social frustration

2,0 [1,7-2,2]

1,8 [1,6-2,1]

depression level

11,3 [9,1-13,5]*

14,9 [14,6-16,5]*

level of jet uneasiness

33,6 [30,1-37,1]

37,8 [34,5-41,1]

level of personal uneasiness

38,1 [34,8-41,4]*

43,7 [42,5-45,9]*

level of the saved-up stress

111,8 [90,4-133,1]*

156,4 [143,2-180,7]*

Correlation analysis in the group of men surveyed revealed an inverse relationship of trait anxiety and the level of Apo-A1 (r = -0,52; p = 0,021), the level of social frustration and Apo-B100/Apo-A1 ratio (r = -0,72; p = 0,000), and the VAS (self-reported health), and Non-HDL cholesterol (r = -0,46; p = 0,048). Moreover, found positive associations with personal relations Apo-B100/Apo-A1 anxiety (r = 0,56; p = 0,012) and depression (r = 0,50; p = 0,028). In the group of women studied were found statistically significant correlations between VAS (self-reported health) of cholesterol - LDL (r = -0,35; p = 0,034), atherogenic index (r = -0,35; p = 0,035), as well as Non-HDL cholesterol (r = -0,37; p = 0,027). There was a negative relationship between the VAS (self-assessment of stress) and the level of Apo-A1 (r = -0,40; p = 0,016).

Multiple regression analysis in men showed an independent effect of trait anxiety on the rate of Apo-A1, the total contribution of this predictor was 17% (p = 0.011). In addition, 15% of the variance of the variable "Apo-B100" due to the influence of a predictor of the "level of social frustration" (p = 0.018). The total contribution of the two predictors (level of social frustration and depression) to the variance of the variable "Apo-V100/Apo-A1 ratio" was 34% (p < 0.05). Also noted independent effect of accumulated stress, as measured on a scale Holmes-Rahe level to Non-HDL cholesterol (R2 = 0,15, β = 0,39, p = 0,004).

The women noted the independent influence of the accumulated stress scale Holmes - Ray on atherogenic index (R2 = 0,11, β = 0,34, p = 0,014), the level of LDL-C and total cholesterol equally (R2 = 0,18, β = 0,42, p = 0,002).

Numerous studies in recent years support the view of a single mechanism by which acute psychological stress causes an increase in the concentrations of total cholesterol and its sub-fractions. In addition, increased levels of cholesterol can occur as a result of changes in the metabolism of lipoproteins themselves.

According to research by L.E. Panin in individuals with high levels of anxiety were all elevated lipid parameters: total lipids, triglycerides, total cholesterol, LDL - cholesterol, HDL - VLDL. Based on the experimental model of stress author found a significant increase in cholesterol content organs and braditrof tissues (aorta), which is a consequence of their fatty infiltration [15].

According to the data of N.P. Garganeeva coronary disease patients with comorbid mood disorders and neurotic character revealed metabolic changes of lipid profile was determined by the phenomenology of mental disorders. In patients with affective disorders observed the highest serum levels of total cholesterol, LDL - cholesterol, atherogenic index, and the downward trend in HDL-C [16].

A. Kempinski, developing ideas corticovisceral and Psychosomatic Medicine, wrote that "every mental state has its biochemical correlates. With further improvement of research methods, we can soon for each mental changes - not only pathological - to find organic correlate, if not morphological, at least, "biochemical" [17].

Conclusion. Established significant gender differences on the studied parameters of lipid profile. The majority of secondary indicators that determine the atherogenic potential, were significantly higher in the group of males surveyed. Dyslipoproteinemia the highest prevalence was found in the group of men, with no significant differences reached a frequency of hypertriglyceridemia and increased levels of apo-B100. The frequency of personal anxiety and clinically significant stress, measured on a scale of Holmes - Rahe, was significantly higher in the group of women surveyed, were, respectively, 75% and 36%. Both groups identified the association of psycho-emotional factors and lipid profile. In this case, the men show an independent relationship between levels of trait anxiety and social frustration with apoproteins, as well as the accumulated stress from cholesterol, non-high-density lipoproteins. The women identified the association of accumulated stress scale Holmes - Rahe with total cholesterol, LDL cholesterol, atherogenic index. These findings point to the need to find ways of creating a comprehensive primary prevention of stress - induced damage metabolism of lipoproteins with the psychoemotional factors and gender characteristics of their influence.

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