Roganov G.G.,
Irza O.L., Nepreluk O.A.
Crimea state
medical university named after S. I. Georgievsky, Simferopol.
The influence the immunomodulator
“Erbisol” on reparation processes in treatment of chronic traumatic
osteomyelitis
Last times due to high level of traumatism the number
of affected from maxillo-facial profile increased 2-fold. Increased the number
of patients, which received the trauma in alcohol intoxication condition.
Despite of the introduction
the new methods of treatment and
improving the existing methods the frequency of pyoinflammatory
complications of trauma, especially
during damages of mandible, stays high and constitute from 5,5 % to 31,9
%.
The issue of medical
prophylaxis and chronic osteomyelitis of mandible treatment related with
nessecary of introduction in clinical practice remedies of new generation, having complex effect of
influence on the human body. This group of remedies includes “Erbisol” . The
preparation is made from cell membrane
of embryonic tissue of cattle. During the experimental and clinical
investigations autors established, that Erbisol has property of activation the recovery processes and improving
the functional activity of organs and tissues.
Also Erbisol promotes the
attenuation of inflammatory processes
due to antioxidant and membrane-stabilizing property.
The purpose of our study
was the learning the proteolytic activity of peripheral blood in patients with chronic traumatic osteomyelitis of
mandible in condition of including in complex of treatment preparaion
“Erbisol”.
Material and methods of
investigation
Were examinated 55 patients, which treated
in maxillofacial surgery department with diagnosis : the chronic traumatic
osteomyelitis of mandible.
The patients were divided into 2 groups. In first control(25) group the
treatment of patients in postoperative
period carried out by traditional method. In second group (30 patients) the
places of tissue, adjacent to sequestration
focus saturated with a mixture of Erbisol and isotonic sodium chloride
0.9%. Also “Erbisol” administered in postoperative period for 10 days. The
patients of first and second group were comparable by anamnesis and prevalence
of the process.
Were collected the blood
from the patients and blood smears
placed in moist chamber and then made fixation and Giemsa stain. Identified 100
neutrophils and determined the level of activity by signs of cell structures
self-digestion .
The proteolytic activity of
blood determined by selective organelles cytolysis.
Results and discussion
The carried out analysiss of indexes of
proteolytic neutrophils activity allowed to establish that patients of first
group of observation had the average
value of indicators 29,2 higher than control.(p<0,01). Next 3-7 days after
surgical treatment observed progressive increase of indexes, which by 7 day was
54,17 % higher than
control(p1<0,05). The decrease of indexes observed by 10-14 day of postoperative
period.
By 21 day of investigation
the proteolytic activity decreased and had statistically insignificant
character (p1-2<0,05) .In main group , where used
preparation Erbisol, noticed
the increase of proteolytic activity of
neutrophils of peripheral blood
lasted till 5 day of investigation, where activity was 41,81 % higher than
control.
In next terms of
investigation the indexes of proteolytic activity of neutrophils had
statistically insignificant character .
In this way the
received by us data testified about
direct correlation between used method of treatment of patients , having
chronic osteomyelitis of mandible in postoperative period and proteolytic activity the enzymes of
neutrophiles of peripheral blood value.
Conclusions:
1.
The course of
chronic osteomyelitis of mandible accompanied by growth of proteolytic activity
of neutrophiles of peropheral blood.
2.
The use in complex treatment antioxidant
therapy has expressive tread and healing effect, this testifed more early
normalization of indexes of proteolysis.