Roganov G.G., Kushnir K.G., Nepreluk O.A.
Crimea state medical university named after S. I.
Georgievsky, Simferopol.
Modern
complex methods of treatment the osteomyelitis of mandible
It
was passed complex treatment of 55 patients with traumatic osteomyelitis of
mandible. During the operation and postoperative period tissues are saturated
by mixture of Erbisol in isotonic sodium chloride solution in correlation 1:5.
In the dynamics of treatment was realized a control of indexes of cytobiochemical
activity of peripheric blood neutrophils. Application of preparation Erbisol directes to manifestation of expressed protector and medical effect.
The number of patients with
damages in maxillofacial field significantlly became high last years because
the increase of level of traumatism.The
problem of prophylaxis and treatment of traumatic osteomyelitis The problem of
prophylaxis and treatment of traumatic osteomyelitis one of the most actual and complicated in surgical stomatology.
It justified by the complicate mechanism of development of suppurative and
destructive process in the bone.
Nowadays the investagators
develop the next main directions: the
learning the issue of etiology and pathogenesis of disease, the improvement the
methods of diagnosis , development and introduction modern methods of treatment
and prophylaxis.
The cause of growth the
number of patients suffering from traumatic osteomyelitis of mandible are: the
late call in the doctor, errors during the before hospital period of treatment,
self-medication, the decrease the
immunity of the body, not right tactics of treatment. The specialist
have good reviews to remidies , which used in first phase of inflammation and
to preparations, demonstrating multidirectional effect.
Such group of preparations includes Erbisol. Esrbisol has effect of
activation the recovery processes and
non-specific immunity, increases the functional activity of organs and tissues.
Materials and methods
Carried out 55 patients in age from 20 to 45 years, which seen a
doctor in maxillofacial department of clinical hospital named after Semashko
with diagnosis :chronic traumatic osteomyelitis of mandible. Were formed 2
groups , comparable by clinical issues , prevalence and sevirity of process.
First group included 25
people (18 male and 7 female), which had the surgical operation and(
sequestration) and treatment in postoperative period conducted by traditional
method. In second (main) group were 30 people( 22 male and 8 female), which had during the operation the places of tissue, adjacent to
sequestration focus saturated with a
mixture of Erbisol and isotonic sodium chloride 0.9%.
Also by cytochemical method
determined the activity of dehydrogenases complex: SDH – activity and
LDH-activity.
Results and discussion
The analysis of
cytobiochemical indexes of periphic blood neutrophils had showed the changes
with different level of reliability. The patients had the decrease of aerobic
oxidation(SDH-activity) by 31,07% and the increase of anaerobic
glycolysis(LDH-activity) by 24,54 %, that testified about tension of metabolism
and anoxaemia. The was in control group
till 7th day.
In the main group, where used preparation Erbisol observed the decrease of SDH-activity .LDH -activity increased.
Conclusions
1. The identified dynamics
of aerobic oxidation and growth of anaerobic glycolysis is reflection of structures changes ,
developing during the osteomyelitis of mandible.
2.
Identified
the significant protector and therapeutic effect of antioxidant “Erbisol”(the
recovery of activity of cytobiochemical indexes of perepheric blood neutrophils
in traditional method of treatment noticed on 14-21 day, and in our
developed method – on 10-14 day.
3.
The used
method of comparable estimation of cytobiochemical indexes activity of peripheric blood neutrophils in patients with osteomyelitis of mandible can be
recommended as diagnostic criterion for control the course of postoperative
period