Index of SMK: 575.191:612.014.24
MARK OF INDICATORS OF THE
HAEMORHEOLOGY AT PATIENTS WITH THE STROKE
B.K.Duyssembayev, A.Sh.Oradova.
The clinical
haemorheology is connected with certain aspects of pathogenesis, diagnostics
and therapies of the diseases accompanied by infringements of microcirculation.
The basic directions of researches are: a syndrome of hyper viscosity of blood,
a cellular haemorheology, and haemorheological aspects of microcirculation.
Key words: ischemic
stroke ,
cardiovascular diseases.
Relevance. Recently, the origin of ischemic stroke, along with
such traditional risk factors like hypercholesterolemia, hypertension much more
await you., Increasing emphasis on the so-called "new" risk factors. These include violations of the
rheological properties of blood (RSK), in particular, aggregation of
erythrocytes and their deformability. According
to some published data, there is a relationship between lipid composition of
blood serum and hemorheology. However, the nature of this connection, in
ischemic stroke studied enough and needs to be clarified [1,2].
Lipid lowering drugs, such as fibrates and statins, not only improves
the lipid composition of blood serum, but also influence the DNC. Nonetheless,
consensus about what parameters DNC and the extent to which undergo changes
during therapy with hypolipidemic drugs did not exist. These circumstances
served as a prerequisite for this study.
Objective: To investigate the
hemorheological parameters in patients with ischemic stroke.
To analyze the relationship between lipid parameters
and hemorheology in ischemic stroke treatment opportunities correction in the
early stages.
Materials and methods: The study
involved 50 patients who were hospitalized in Clinical Hospital № 7, Almaty (21
men and 29 women) ─ the average age of 54,9 ± 1,8 years with ischemic
stroke.
Determination of lipid profile (total cholesterol, LDL, HDL, TG),
transaminases, CK was performed on an automatic analyzer Cobas - 400 using
enzymatic kits firm Roche. We determined the following parameters of the
rheological properties of blood (RSK): yield strength (PT), the apparent
viscosity (KV), kessonovskuyu viscosity (SWR), the coefficient of cohesion of
erythrocytes (KKE), while the fast (T1) and slow (T2), erythrocyte aggregation,
the hydrodynamic resistance units (GPU), the amplitude of aggregation (AA) red
cells.
Results and discussion. In
patients with ischemic stroke significantly violated viscosity characteristics
of blood, as well as aggregation and deformability of erythrocytes. In the most
pronounced changes were RSK, which was significantly correlated with the level
of TG in serum (r = 0,7, p <0.01 for PT). Deformability of erythrocytes was
reduced in all patients (p <0,05).
Conclusion. In patients with ischemic stroke should be assessed and the DNC to
hold their correction, as the hospital and outpatient phases of treatment that
optimizes medication therapy related pathological states [3].
Bibliography
1. Levtov VL, Regirer SA,
Shadrina NH Rheology of blood. M.: Med., 1982. ─ 272.
2. Firsov NN, IV Sirko,
Priezzhev AV Recent developments in the whole blood aggregometry / thrombosis,
hemostasis and rheology. ─ 2000. ─ № 2 (2). ─ pp 9-11
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3.
Schmid-Schönbein H. Blood rheology and physiology of microcirculation. In:
Disorders of blood flow, new therapeutic aspects. Ed. R.V.Manrigue, R.Muller,
Amsterdam-Oxford-Princeton, 1981, p.1-23.