Pridatko I.S., Kushnir K.G., Nepreluk O.A., Rohan G.G.

Crimea State Medical University named after S. I. Georgievsky

Changing the speed of salivation in orthopedic patients with a syndrome of intolerance.

The problem of intolerance to the materials used in medicine remains today one of the most pressing . This is due to the following circumstances. First, the continuously increasing number of medicines and materials used for therapeutic purposes as well as for replacing lost or missing tissues and organs. Second, change the reactivity of the human body as a result of increasing antigenic load from the external environment against adverse environmental conditions . Third, the ever-increasing emotional stress , cause the restructuring of human neuro , which reduces resistance to other external factors , including the nature of the substances antigen . This may to some extent explain the large increase in allergic diseases in both developed and developing countries. Among the materials commonly used in medicine and in the domestic sphere , widely used plastic. And with plastics that are used in medical practice , including in dentistry greatest popularity belongs acrylates . The number of patients who use dentures from acrylic plastic is continuously growing due to an increase in life expectancy of people and widespread pathology of the hard tissues of the teeth and periodontal - the main cause of tooth loss .

Simultaneously with the increase in the number of people using dental prosthesis , an increasing number of patients who can not use them for various reasons. Clinically , patients have marked changes in the tissues of the mouth, due to both allergic and non-specific inflammation , burning and other non- pleasant feelings . Among the many causes of intolerance , which are subsequently discussed in our review of literature , an important place belongs to the chemical and toxic- allergic effects , leading to general and local pat.

Found that the development syndrome patients hypersensitive to acrylic resin is a reaction expressed by the organism, as evidenced by an increase in oxidation, and trypsin activity antitripticheskoy mixed saliva against the functional activity of the salivary glands, the aerobic oxidation and reduction of the growth of anaerobic glycolysis, increase the bioelectric activity of the oral cavity, and and the prevalence of anaerobic over aerobic microflora.

In the group of healthy subjects (control group) rate of speed salivation was 0,67 ± 0,028 ml / min. After you install the removable plate dentures of acrylates, salivation rate increased by 19.4% (P <0.05) and amounted to 0,80 ± 0,035 ml / min.During monitoring of clinical and laboratory studies in orthopedic patients after installing removable plate dentures from acrylic plastic (group 1 cases) revealed that within a month after the performance of prosthetic Schiller- Pisarev increased by 46 % and amounted to 1,65 ± 0 , 18 points , a similar pattern was observed in the analysis of the speed salivation , which by this time was higher benchmarks by 19.4 % and amounted to 0,80 ± 0,35 ml / min, the biopotentials mouth increased by 15.4 % and accounted for 180 ± 4,0 mV.

All of the foregoing has allowed us to assume and conclude that orthopedic patients after installing removable plate dentures from acrylic plastic for 1 month there was a significant bearing the character of a statistically significant, the shift of the studied parameters, which, in our opinion, is the body's reaction to the patient acrylates and is regarded by us as a syndrome of intolerance. It was revealed that the syndrome of intolerance in orthopedic patients wearing removable dentures from acrylic laminar plastics causes significant impairment of the enzymatic activity of mixed saliva, which are confirmed in an increase in the antioxidant activity of 14.7%, antitripticheskoy activity by 17.2%, trypsin activity by 17 3%.

To speed up the process of adaptation and mitigation of adverse events is recommended to use prebiotics "Biodent - 4".