Voynalovich A.S. Kolbasina R.A.
Crimean
Agrotechnological University
The method of pharmacological contact
hemostasis.
The method of obtain the
substance for pharmacological contact
hemostasis which not react with blood
and not seal the wound during the swelling remains today one of the most pressing. As a base of the substance
used fine-grained chitosan, added lyophilized antiseptic, mixed them and packed
in tight hermitc packaging.
This usefull model related
to veterinary science and can be used for stop the open bleeding of any severity.
The most close to this
is patent “Clay-based hemostatic
agents” USA ¹ 7968114. Its essence is that formed fine-grained koalin-based powder (argil). This powder is used for stop
the bleeding from open wounds, he does not interacts with the blood and seals the wound due to swelling during the contact with blood.
Shortcomings of the
prototype are:
1.
Hemostatic
agent based on kaolin hygroscopic, that's why in case of insignificant damage
of packaging he loses his properties.
2.
Hemostatic
agent based on kaolin hasn't antimicrobial properties , that's why in case of
semination of pathogenic microflora can develope infectional complications.
The purpose of this usefull
model is elimanation of pointed shortcomings by creating drugs in the form of
powder for pharmacological contact hemostasis , which has not
expressive hygroscopicity and has antimicrobial properties.
This problem is solved by obtaining the substance for
pharmacological
contact hemostasis, for
this to 10-20 gm fine-grained chitosan
added 8-10 gm of freeze-dried antiseptic, for example miramistin, mixed them ,
and packed in tight sealed container.
The addition of antiseptic
provides:
-
disinfection
of wound during infliction of contact hemostatic
-
prevention
the reproduction of microorganisms in wound during long hemostasis
-
Acceleration of wound healing
and tissues regeneration
The use chitosan
in the composition of substance prevents damage of preparation during
the transportation and wear in extreme conditions, because of that
it less hygroscopic than kaolin. He doesnt react with blood and body tissues ,
and he isnt growing medium for microorganisms.
The embodiment of the
method.
Placed in a
container a 10 gm of fine-grained
chitosan, added 5 mg freeze-dried
miramistin , after thoroughly stirred the mixture and the packed tight
sealed packaging.
Practice shows , that
the substance for pharmacological contact hemostasis allows to speed up
healing of open wounds during the stop bleeding by this preparation, and also
prevents reproduction of microorganisms in the wound during long-term use of
hemostatic agent. The presence of an antiseptic miramistin in the wound
stimulates regeneration of tissues and inhibits the proliferation of pathogenic
organisms.
The assigned task - elimination the disadvantages of the
prototype - confirms it all.
The carried out patent
investigations allows to make a conclusion, that the substance , similar to
ours , with pointed utility model. This model has the set of distinctive
features and unknown in different medical investigation
and developments. Therefore
this model is new.
In the inventive
substance during it receive used known
ingredients: chitosan, freeze-dried miramistin.
Conclusion
The new method of receive
the substance for pharmacological contact hemostasis is new model related to veterinary science and can be used for
stop the open bleeding of any severity. This model is used for stop the bleeding from open wounds, he does not
interacts with the blood and seals the
wound due to swelling during the
contact with blood. Therefore this model can be used stop the bleeding from open wounds.