Медицинские науки/ 1. Акушерство и гинекология

Medical sciences / 1. Obstetrics and Gynecology

Syusyuka V.G., Peycheva E.V., Gorbacheva S.V.

State Medical University of Zaporozhye, Ukraine

Maternity hospital No. 9, Zaporozhye, Ukraine

LEVEL OF magnesium of pregnant women with noncarrying of pregnancy in the past history

Key words: pregnancy, miscarriage, macroelements, magnesium, psychoemotional state, anxiety level.

Introduction. High biological activity and physiological significance of many macro- and microelements and their complicated relations in physiological and especially pathological states stipulate importance of their comprehensive investigation [11]. Insufficient receipt of vitamins and biometals by organism of the pregnant woman is the main reason for increase of rate of gestation complications and rise of percentage of common diseases [9].

Lack of magnesium during pregnancy can cause undesirable consequences both for the mother and fetus: abnormality of fetus implantation, calcinosis of placenta (consequence of calcium metabolic imbalance in conditions of magnesium deficit), long-term threatening miscarriage, premature delivery, weak labour activity, abnormal cervical dilatation during expulsion of fetus, symphysiopathy, symphysitis, preeclampsia and eclampsia [2, 3, 4, 5, 10].

Object. Estimate macroelementary homeostasis of women with physiological and complicated course of pregnancy regarding psychoemotional state.

Examined group and methods. There were examined 36 pregnant women with miscarriage in the past medical history with gestation term of 22-34 weeks (the main group) and 29 pregnant women without somatic pathology and clinical picture of miscarriage in the past medical history (control group). Concentration of magnesium, calcium, potassium, sodium, chlorine was determined by set of instruments for diagnostics in blood serum. Individual and psychological peculiarities of pregnant women and their psychoemotional state were investigated by means of complex of psychodiagnostic methods: State and trait anxiety (SA, TA) scale of Spielberger-Hanin, Eysenck Personality Questionnaire (EPQ) and questionnaire for energy, activity and mood [6, 7, 8].

Results and conclusions. Based on performed investigation of psychological state of pregnant women with miscarriage in the past medical history there was determined statistically proved prevalence (p <0.05) of level of neuroticism, state and trait anxiety comparing to the control group of pregnant women. Mutual influence of above mentioned indices is confirmed by available correlative relationship and is an evidence of psychoemotional misadaptation of the present group of women. Level of magnesium in the group of women with miscarriage in the past medical history, which had made 0.85 ± 0.07mmol/l, was statistically proved (p <0.05) and lower than the correspondent index of the control group – 0.97 ± 0.07mmol/l but its significant decrease occurred only to women with high state and trait anxiety (SA, TA) level and it can indicate exhaustion of magnesium reserve associated with psychoemotional misadaptation. Results of performed investigation permit to determine dependence between decrease of magnesium concentration and increase of neuroticism level and both level of SA (r = -0.589, p <0.05) and TA (r = -0.631, p <0.05). But among pregnant women with magnesium concentration, which was close to the upper limit, SA level was average in most part of cases. Taking into account that SA is sign of so-called emotional reaction on the stress situation and is characterized by psychologically experienced emotions, high level of magnesium in blood serum of the present group of pregnant women should be considered as one of adaptation mechanisms.

Literature

1. Astakhov V.M., Batsyleva I.V., Puz' I.V. (2010) Psychodiagnostic methods individual psychological characteristics of women in obstetric and gynecological clinic. Donetsk: Nord-Press, 199.

2. Chekman I. S., Gorchakova N. A., Nikolaj S. L. Magnesium in medicine. Kishinev, 101.

3. Gromova O. A. (2006). Vitamins and minerals during pregnancy and in nursing mothers. Clinical pharmacology. Educational programs of UNESCO. Edited by V. M. Sidel'nikovoj. Moscow, 58.

4. Hashukoeva A.Z, Hlynova S.A., Narimanova M.R., Karelina L.A. (2014). The role of magnesium in a woman's life. Akusherstvo i ginekologija, 12, 37-41.

5. Kosheleva N. G., Arzhanova O. N., Pluzhnikova T. A. (2003) Miscarriage: etiopathogenesis, diagnosis, clinic and treatment. Sankt-Peterburg, 70.

6. Malkina-Pyh I.G. Psihosomatika (2010). Moscow: Jeksm, 1024р.

7. Mendelevich V.D. (2008) Clinical and Health psychology. Moscow: MEDpress-inform, 432.

8. Rajgorodskij D.Ja. Practical psychodiagnosis (2002). Samara: «Bahrah-M», 672р.

9. Takase B., Akima T., Uehata A. et al. (2004). Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin. Cardiol., 27(4), 223-227.

10. Tetruashvili N. K., Sidel'nikova V. M. (2005). Completion of magnesium deficiency in the treatment of patients with threatened miscarriage. Trudnyj pacient, 2, 20-23.

11. Zaporozhan V.N., Gozhenko A.I., Mishhenko V.P. (2001). Modern views on gestational microelementoses. Vіsnik Asocіacії akusherіv-gіnekologіv Ukraїni, 1, 6-11.