Hydration of tissue in woman with impaired reproductive function with

hypothyroidism

Oksyuta V.

Rivne Medical College

Problem statement

Tissue hydration status is an important indicator in the choice of medical treatment

of the women»s reproductive function. This is especially true for woman with the inadequate thyroid function mode, where the extra weight is not formed due to the increase in fat mass, but due to edema of myxedema ( The increased deposition of glycosaminoglycans leads to osmotic edema and fluid collection ). In this case, the use of body mass index volume is uninformative.

Methods:

To assess the body composition, we have used the method of bioimpedans measurements using the device, which determines the degree of hydration of tissues ИСГТ-01, which allows to determine the electrical resistance of biological tissues at different frequencies. Measuring the electrical resistance at low frequencies ( active resistance ) the number of extracellular fluid is determined.

Measuring the electrical resistance at high frequencies the capacitive resistance and quantity of intracellular fluid is determined. Thus, having determined the number of intracellular and extracellular fluid may be revealed the presence or absence of specific edema and installation of the body»s weight.

It was conducted the survey of 59 women of active reproductive age who complained of lack of pregnancy during one year or more. Among them, 27 woman had subclinical hypothyroidism, 32 women had manifest hypothyroidism.

The surveys had been conducted before replacement levothyroxine. The control group was of similar age and contained 41 healthy women.

In the analysis of the received data it was found a significant decrease of the active resistance of biological tissues among the women with hypothyroidism ( 1,36 ± 0,01 kOm ) vs 1,70 ± 0,06 kOm the healthy group, and as a consequence there was a significant increase in extracellular fluid to 14,37 ± 1.53 liters among the women with hypothyroidism vs 11,42 ± 0,82 l ( in the healthy group ).

Differences in the state of tissue hydration between the groups of women with subclinical hypothyroidism, manifest hypothyroidism and the healthy group were not found.

Conclusion:

Woman with reproductive disorders on the background of hypothyroidism have distinct changes of tissue hydration by increasing the extracellular fluid.

Among women who have normal values of thyroid hormones even at a high content of thyroid stimulating hormone ( subclinical hypothyroidism ) changes in tissue hydration were not found.

When planning the treatment of reproductive disorders the state of tissue hydration among women with hypothyroidism should be taken into consideration.