Kolbasin P.N. Kazyuta
T.G., Shuman M.D., Antonov A.V.
Crimea state
medical university named after S. I. Georgievsky, Simferopol.
The modified method of pharmacological contact hemostasis
The method of obtain the
substance for pharmacological contact
hemostasis which not react with blood
and not seal the wound during the swelling remains today one of the most pressing. As a base of the substance
used fine-grained chitosan, added lyophilized antiseptic, mixed them and packed
in tight hermitc packaging.
This usefull model related
to medicine and can be used for stop
the open bleeding of any severity.
The most close to this
is patent “Clay-based hemostatic
agents” USA ¹ 7968114. Its essence is that formed fine-grained koalin-based powder (argil). This powder is used for stop
the bleeding from open wounds, he does not interacts with the blood and seals the wound due to swelling during the contact with blood.
The signs , with
associated with the signs of method-prototype is the use the substance of
natural origin with adsorption properties.
The signs, which prevents
the achievement of expected technic matherial: hemostatic agent based on
coalin, it has enveloping and absorbing
effect, but he does'not have antimicrobial properties, therefore in case of
semination of pathogenic microflora during the long use of hemostatic agent may
develop infection complications.
Hemostatic agents are made for stop bleeding for an hour and a few hours , and during this time may appear the
reproduction f pathogenic microflora,
and hemostatic agent based on coalin , therefore in case of insigificant damage
of packaging he loses his properties, especially during the transportation in
extreme conditions, it leads to significant lose of these properties.
The technical result: the
increase of efficiency of pharmacologic contact hemostasis.
At the base of usefull
model made the object of improvement the the method-prototype.
The assigned task solved
by the method of pharmacologic hemostasis, which include the use of substance
of nature origin made of medical substance, which doesnt have expressive.
The purpose of this
usefull model is elimanation of pointed shortcomings by creating drugs in the
form of powder for pharmacological contact hemostasis , which has not
expressive hygroscopicity and has antimicrobial properties.
Practice shows , that
the substance for pharmacological contact hemostasis allows to speed up
healing of open wounds during the stop bleeding by this preparation, and also
prevents reproduction of microorganisms in the wound during long-term use of
hemostatic agent. The presence of an antiseptic miramistin in the wound
stimulates regeneration of tissues and inhibits the proliferation of pathogenic
organisms.
Chitosan – amino sugar,
derivative of linear polysugar, and besides the molecule of chitosan contains
the big amounts of free aminogroups, it allows to receive ions of different metals, and toxoc substances.
It was determined, that
chitosan has antimicrobial activity and can absorbe biological liquid and help
to tissue regeneration.
In the inventive
substance during it receive used known
ingredients: chitosan, freeze-dried miramistin.
The embodiment of the
method.
Placed in a
container a 10 gm of fine-grained
chitosan, added 5 mg freeze-dried
miramistin , after thoroughly stirred the mixture and the packed tight
sealed packaging.
Practice shows , that the
substance for pharmacological contact hemostasis allows to speed up
healing of open wounds during the stop bleeding by this preparation.
Conclusion
This method of
pharmacological hemostasis allows to
decrease the bleeding , to hurry of healing of open wound , and does not let to microorganisms reproduction
during use hemostasis. This all justified the obtaining of made object. The
instruction of use very simple, and do not require special medical knowledge.
The new method of receive
the substance for pharmacological contact hemostasis is new model related to medicine and can be used for stop the
open bleeding of any severity.