Fazullin F.U.
Bashkir State Medical University, Ufa, Russia
THE POSSIBILITY OF
APPLYING AUTOLOGOUS PLATELET PLASMA IN DENTISTRY
Efficacy, safety and low invasiveness — the main
requirements for modern technologies in medicine. These qualities satisfy the
technology of application of autologous platelet plasma (TAP) is a method
Plasmolifting, outdoor and patented by Russian scientists Ahmerov R. R. and
Zarudy R. F. In addition to the method of dentistry has been successfully
applied in dermatology and cosmetology, obstetrics and gynecology, orthopedics
and traumatology, neurology, sports medicine. The principle of the method lies
in the introduction of the TAP into tissue and receiving the effect of
stimulation of natural mechanisms of regeneration at the expense contained in
the platelet growth factors (TGF) to promote regeneration of damaged tissues.
Get TAP of venous autologous blood of the patient by centrifugation in a
certain mode in a specialized test tube Plasmolifting with a separator gel and
an anticoagulant, by separating plasma and platelets from red blood cells by
density gradient and using specialized laboratory filters [1,4,6]. TAP was used
to stimulate the osteogenesis of bone defects of the facial skeleton
platelet-rich plasma, as a factor contributing to the increase in the number of
osteoinductive morphogenetic protein ("BMP — bones morphogenetic
protein"), roadsteads works with data on a strong osteogenic and
chondrogenic activity of the substance contained in alfagroup platelets [3]. In
the future, this technique has found a wide application in various fields of
medicine: cardiology, entitled "platelet concentrate" or
"platelet gel," in oral and maxillofacial surgery, where this
methodology was used to improve the quality of regeneration and acceleration of
implantation[4]. The use of TAP in complex treatment of inflammatory
periodontal diseases (VPP) is the first area of dentistry, where he began to
apply the method. According to studies, using injections of TAP in complex
treatment of periodontitis accelerates the relief of the inflammatory process,
reduces treatment time, prevents the development of necrotic-destructive
processes; prevents the development of sclerosis, helps to stabilize the bone
trabecular structures and bone tissue growth, gives long-lasting clinical
remission, stable level values of the periodontal indices, reduction in depth
of periodontal pockets [1,4,6].
The method is applied of therapeutic stomatology at
treatment of periodontitis [9], diseases of the oral mucosa [4, 7] in
periodontics for treatment of periodontal disease. gingivitis and for the
prevention of inflammatory complications in pacanow risk groups: after dental
implantation [5], during orthodontic treatment [7,8], c concomitant diseases
(e.g. diabetes mellitus), in cases where surgical treatment is contraindicated
in the complex conservative therapy [7]. To date, the introduction of the
platelet autoplasma can be done in two basic methods. The first method involves
the introduction of the required volume of platelet autoplasma only in the area
of transitional fold. The second method involves the introduction of platelet
autoplasma as a transitional fold, in the area of the gingival papilla and
marginal gingiva [5,6,7]. Using this method in periodontics and prevention
before the procedure in all cases conducted professional hygiene of the oral
cavity. Injection of platelet autoplasma can be carried out on the same day
immediately after the removal of dental plaque or in the next 2-3 days.
[5,6,7]. Treatment of periodontal disease can be carried out courses. One
course consists of 3-4 procedures (1 to 2 vials per visit). The use of technology
PlasmoliftingTM of dentistry, periodontitis 7-14 days after the first
injection, volume of injected plasma is 3.5±0.5 ml for one dental segment
consisting of 6-8 teeth. Repeat the treatment 2-3 times a year, depending on
the severity of the disease [5,6,7]. Plasmolifting method does not preclude the
appointment of antibacterial, anti-inflammatory, anti-edematous,
immunomodulatory and immunostimulatory drugs [7]. It should be noted that in
some cases already after one week you can see the first therapeutic effect of
the treatment using plasma, which is manifested by improvements of hygienic and
periodontal indices, and hence the reduction of bleeding gums and the gingiva
of normal color [5,6]. Thus, using injections of platelet autoplasma in
dentistry allows you to stop inflammation of the gums; reduce pain; enhance
engraftment of the implant; reduce bleeding gums; the timing of recovery of periodontal tissues
after surgical intervention; to accelerate the recovery of tissues from
patients with diabetes mellitus.
List of
used literature:
1. Ахмеров
Р.Р., Овечкина М.В., Цыплаков Д.Э., Воробьев А.А., Мансурова Т.Г. Технология Plasmolifting — инъекционная форма тромбоцитарной
аутоплазмы для лечения хронических пародонтитов I–II степени
тяжести // Пародонтология. — 2013. — № 1 (66). — С. 45–47.
2.
Ахмеров
Р.Р., Зарудий Р.Ф., Овечкина М.В., Цыплаков Д.Э., Воробьев А.А. Технология Plasmolifting — инъекционная форма тромбоцитарной аутоплазмы для лечения хронических катаральных гингивитов // Пародонтология. — 2012. — № 4 (65). — С. 80–84.
3. Брехов
В.Л. Хирургическое лечение больных с дефектами костной и хрящевой тканей с
применением богатой тромбоцитами аутоплазмы. дис. канд. мед. наук. Курск. -
2007г
4. Гуляева
О.А. Возможности применения тромбоцитраной аутологичной плазмы в стоматологии.
// Dental
Magazine. 2017. № 3. С. 26-29.
5. Гуляева О.А., Аверьянов С.В. Профилактика воспалительных
осложнений после дентальной имплантации // Пародонтология. – 2017. – № 2. – С.
84-88.
6. Гуляева О.А., Аверьянов С.В., Солодкий В.Г.,
Овечкина М.В., Ахмеров Р.Р., Зарудий Р.Ф., Тухватуллина Д.Н., Саляхова Г.А.
Применение аутологичной тромбоцитарной плазмы в стоматологии. Уфа, 2016.
7. Гуляева О.А., Тухватуллина Д.Н., Солодкий В.Г.
Применение тромбоцитарной аутологичной плазмы в
комплексном лечении и профилактике гингивита у пациентов с несъемными
ортодонтическими конструкциями // Пародонтология. –
2016. – № 2. – С. 38-42.
8. Гуляева О.А. Способ
лечения гипертрофического гингивита у пациентов с несъемной ортодонтической
техникой с применением инъекционной формы аутологичной тромбоцитарной плазмы / патент на изобретение
RUS 2626826 08.11.2016
9. Гуляева О.А., Буляков Р.Т. Способ лечения деструктивных форм
хронического периодонтита с применением инъекционной формы аутологичной
тромбоплазмы / патент на изобретение
RUS 2627582 25.05.2016