Медицинские науки/ 1. Акушерство и гинекология

Medical sciences / 1. Obstetrics and Gynecology

PhD of Medical Science, A.P., Syusyuka V.G.

State Medical University of Zaporozhye

Department of Obstetrics and Gynecology

Estimation of anxiety influence on cortisol and insulin level of pregnant women

Now it is proved that mental life of prenatal developing baby is active and mainly depends on emotions and feelings of the mother and the most important thing is that it is the foundation of psycho-emotional characteristics of the baby for many future years [1].

Anxiety of the mother during stress causes disorders in functioning of her organs and systems besides it disturbs biochemical balance of the fetus leading to hyperactivation of sympathoadrenal system (SAS) [7]. State of the pregnant woman can have significant influence on features of the prenate psychological functions which are being formed and therefore it can considerably determine his life scenario [2].

Prenatal negative effects have the strongest destructive influence. If during pregnancy mother had severe stress, intensive anxiety or depression or took glucocorticoids this could lead to reduction of weight and body size of fetus by delivery, decrease of hippocampus size and cellular damages in the brain [6]. Increase of concentration of the main stress hormone (cortisol) in the mother’s blood leads to enzyme destroying it in placenta can not cope anymore with stress and mother’s cortisol comes into blood of fetus. Artificially created stress condition is occured [4].

Object of investigation: to estimate cortisol and insulin level and their ratio among pregnant women considering anxiety level.

Group of examined women and methods of investigations There was the examined 65 pregnant women with gestation term of 26-32 weeks. Mean age of examined women made 26.9±0.95 years. The main group includes 45 pregnant women with middle and high level of state anxiety (ST). Control group is presented by 20 pregnant women with anxiety level of 30 points and lower that defines the low ST level. Psycho-emotional state of pregnant women was estimated on the basis of structured interview and assessment of anxiety level under Spielberg-Hanin method [3, 5]. Quantitative estimation of cortisol and insulin concentration in blood plasma was determined by enzyme-linked immunoassay by means of “SIRIO S” device with DRG test system (USA).

Results of investigation and their discussion

Based on investigation of 65 pregnant women with gestation term of 26-32 weeks it was found that more than 90% of pregnant women have trait anxiety. Such results give possibility to suppose major role of individual characteristics of the person in development of both anxiety and other changes of psychoemotional state. This fact is confirmed by available correlation relationship between the trait anxiety and state anxiety (r = +0.408, p < 0.05) and index of anxiety in accord with Induvidual typologic questionnaire (r = +0.422, p < 0.05), with neurotism level (r = +0.586, p < 0.05) and also negative influence on state of health (r = -0.399, p < 0.05).

Conclusions

Based on results of hormonal profile estimation there was found that pregnant women with high and middle level of the state anxiety have indicators of both cortisol and cortisol/insulin indices were statistically higher (p>0.05) than appropriate indicators of pregnant women with low state anxiety level.

Direct influence of the state anxiety on rise of K level and cortisol/insulin index have only pregnant women with high and middle levels of the state anxiety and it is proved by available correlation relationship (r = +0.692, p < 0.05) and (r = +0.580, p < 0.05), correspondingly.

Literature

1. Bragina M. Perspective: through the eyes of a psychologist pregnancy (2010). Z turbotoju pro zhіnku, 7(19), 8-11.

2. Dobryakov I.V. Perinatal'naya psikhologiya (2009). Saint Petersburg: Piter, 234p.

3. Malkina-Pyh I.G. Psihosomatika (2010). Moscow: Jeksm, 1024р.

4. Poljakova O. N. Stress: сauses, сonsequences, overcoming (2008). Saint Petersburg: Rech', 144р.

5. Rajgorodskij D.Ja. Practical psychodiagnosis (2002). Samara: «Bahrah-M», 672р.

6. Rozanov Stress and mental health (2013). Social'naja i klinicheskaja psihiatrija, 1, 79-86.

7. Vdovichenko Yu.P., Zhuk S.I., Shchurevskaya O.D. (2014) Support for pregnancy and childbirth in conditions of social stress. Kyiv: ChP «Print Layn», 64.